| Date | Matchup | Time (EST) |
| Thursday, Sept. 4 | Washington Redskins at New York Giants | 7 p.m. |
| Sunday, Sept. 7 | Cincinnati Bengals at Baltimore Ravens | 1 p.m. |
| Sunday, Sept. 7 | New York Jets at Miami Dolphins | 1 p.m. |
| Sunday, Sept. 7 | Kansas City Chiefs at New England Patriots | 1 p.m. |
| Sunday, Sept. 7 | Houston Texans at Pittsburgh Steelers | 1 p.m. |
| Sunday, Sept. 7 | Jacksonville Jaguars at Tennessee Titans | 1 p.m. |
| Sunday, Sept. 7 | Detroit Lions at Atlanta Falcons | 1 p.m. |
| Sunday, Sept. 7 | Seattle Seahawks at Buffalo Bills | 1 p.m. |
| Sunday, Sept. 7 | Tampa Bay Buccaneers at New Orleans Saints | 1 p.m. |
| Sunday, Sept. 7 | St. Louis Rams at Philadelphia Eagles | 1 p.m. |
| Sunday, Sept. 7 | Dallas Cowboys at Cleveland Browns | 4:15 p.m. |
| Sunday, Sept. 7 | Carolina Panthers at San Diego Chargers | 4:15 p.m. |
| Sunday, Sept. 7 | Arizona Cardinals at San Francisco 49ers | 4:15 p.m. |
| Sunday, Sept. 7 | Chicago Bears at Indianapolis Colts | 8:15 p.m. |
| Monday, Sept. 8 | Minnesota Vikings at Green Bay Packers | 7 p.m. |
| Monday Sept. 8 | Denver Broncos at Oakland Raiders | 10:15 p.m. |
| Date | Matchup | Time (EST) |
| Sunday, Sept. 14 | Tennessee Titans at Cincinnati Bengals | 1 p.m. |
| Sunday, Sept. 14 | Buffalo Bills at Jacksonville Jaguars | 1 p.m. |
| Sunday, Sept. 14 | Oakland Raiders at Kansas City Chiefs | 1 p.m. |
| Sunday, Sept. 14 | Indianapolis Colts at Minnesota Vikings | 1 p.m. |
| Sunday, Sept. 14 | Chicago Bears at Carolina Panthers | 1 p.m. |
| Sunday, Sept. 14 | Green Bay Packers at Detroit Lions | 1 p.m. |
| Sunday, Sept. 14 | New York Giants at St. Louis Rams | 1 p.m. |
| Sunday, Sept. 14 | New Orleans Saints at Washington Redskins | 1 p.m. |
| Sunday, Sept. 14 | Atlanta Falcons at Tampa Bay Buccaneers | 4:05 p.m. |
| Sunday, Sept. 14 | San Francisco 49ers at Seattle Seahawks | 4:05 p.m. |
| Sunday, Sept. 14 | New England Patriots at New York Jets | 4:15 p.m. |
| Sunday, Sept. 14 | San Diego Chargers at Denver Broncos | 4:15 p.m. |
| Sunday, Sept. 14 | Miami Dolphins at Arizona Cardinals | 4:15 p.m. |
| Sunday, Sept. 14 | Baltimore Ravens at Houston Texans | 4:15 p.m. |
| Sunday, Sept. 14 | Pittsburgh Steelers at Cleveland Browns | 8:15 p.m. |
| Monday, Sept 15 | Philadelphia Eagles at Dallas Cowboys | 8:30 p.m. |
| Date | Matchup | Time (EST) |
| Sunday, Sept. 21 | Kansas City Chiefs at Atlanta Falcons | 1 p.m. |
| Sunday, Sept. 21 | Oakland Raiders at Buffalo Bills | 1 p.m. |
| Sunday, Sept. 21 | Cincinnati Bengals at New York Giants | 1 p.m. |
| Sunday, Sept. 21 | Miami Dolphins at New England Patriots | 1 p.m. |
| Sunday, Sept. 21 | Houston Texans at Tennessee Titans | 1 p.m. |
| Sunday, Sept. 21 | Tampa Bay Buccaneers at Chicago Bears | 1 p.m. |
| Sunday, Sept. 21 | Arizona Cardinals at Washington Redskins | 1 p.m. |
| Sunday, Sept. 21 | Carolina Panthers at Minnesota Vikings | 1 p.m. |
| Sunday, Sept. 21 | New Orleans Saints at Denver Broncos | 4:05 p.m. |
| Sunday, Sept. 21 | Detroit Lions at San Francisco 49ers | 4:05 p.m. |
| Sunday, Sept. 21 | St. Louis Rams at Seattle Seahawks | 4:05 p.m. |
| Sunday, Sept. 21 | Jacksonville Jaguars at Indianapolis Colts | 4:15 p.m. |
| Sunday, Sept. 21 | Pittsburgh Steelers at Philadelphia Eagles | 4:15 p.m. |
| Sunday, Sept. 21 | Cleveland Browns at Baltimore Ravens | 4:15 p.m. |
| Sunday, Sept. 21 | Dallas Cowboys at Green Bay Packers | 8:15 p.m. |
| Monday, Sept. 22 | New York Jets at San Diego Chargers | 8:30 p.m. |
| Date | Matchup | Time (EST) |
| Sunday, Sept. 28 | Cleveland Browns at Cincinnati Bengals | 1 p.m. |
| Sunday, Sept. 28 | Houston Texans at Jacksonville Jaguars | 1 p.m. |
| Sunday, Sept. 28 | Denver Broncos at Kansas City Chiefs | 1 p.m. |
| Sunday, Sept. 28 | Atlanta Falcons at Carolina Panthers | 1 p.m. |
| Sunday, Sept. 28 | Arizona Cardinals at New York Jets | 1 p.m. |
| Sunday, Sept. 28 | San Francisco 49ers at New Orleans Saints | 1 p.m. |
| Sunday, Sept. 28 | Green Bay Packers at Tampa Bay Buccaneers | 1 p.m. |
| Sunday, Sept. 28 | Minnesota Vikings at Tennessee Titans | 1 p.m |
| Sunday, Sept. 28 | San Diego Chargers at Oakland Raiders | 4:05 p.m. |
| Sunday, Sept. 28 | Buffalo Bills at St. Louis Rams | 4:05 p.m. |
| Sunday, Sept. 28 | Washington Redskins at Dallas Cowboys | 4:15 p.m |
| Sunday, Sept. 28 | Philadelphia Eagles at Chicago Bears | 8:15 p.m. |
| Monday, Sept. 29 | Baltimore Ravens at Pittsburgh Steelers | 8:30 p.m. |
| Date | Matchup | Time (EST) |
| Sunday, Oct. 5 | Tennessee Titans at Baltimore Ravens | 1 p.m. |
| Sunday, Oct. 5 | Kansas City Chiefs at Carolina Panthers | 1 p.m. |
| Sunday, Oct. 5 | Indianapolis Colts at Houston Texans | 1 p.m. |
| Sunday, Oct. 5 | San Diego Chargers at Miami Dolphins | 1 p.m. |
| Sunday, Oct. 5 | Chicago Bears at Detroit Lions | 1 p.m. |
| Sunday, Oct. 5 | Atlanta Falcons at Green Bay Packers | 1 p.m. |
| Sunday, Oct. 5 | Seattle Seahawks at New York Giants | 1 p.m. |
| Sunday, Oct. 5 | Washington Redskins at Philadelphia Eagles | 1 p.m. |
| Sunday, Oct. 5 | Tampa Bay Buccaneers at Denver Broncos | 4:05 p.m. |
| Sunday, Oct. 5 | Cincinnati Bengals at Dallas Cowboys | 4:15 p.m. |
| Sunday, Oct. 5 | Buffalo Bills at Arizona Cardinals | 4:15 p.m. |
| Sunday, Oct. 5 | New England Patriots at San Francisco 49ers | 4:15 p.m. |
| Sunday, Oct. 5 | Pittsburgh Steelers at Jacksonville Jaguars | 8:15 p.m. |
| Monday, Oct. 6 | Minnesota Vikings at New Orleans Saints | 8:30 p.m. |
| Date | Matchup | Time (EST) |
| Sunday, Oct. 12 | Miami Dolphins at Houston Texans | 1 p.m. |
| Sunday, Oct. 12 | Baltimore Ravens at Indianapolis Colts | 1 p.m. |
| Sunday, Oct. 12 | Cincinnati Bengals at New York Jets | 1 p.m. |
| Sunday, Oct. 12 | Oakland Raiders at New Orleans Saints | 1 p.m. |
| Sunday, Oct. 12 | Chicago Bears at Atlanta Falcons | 1 p.m. |
| Sunday, Oct. 12 | Detroit Lions at Minnesota Vikings | 1 p.m. |
| Sunday, Oct. 12 | Carolina Panthers at Tampa Bay Buccaneers | 1 p.m. |
| Sunday, Oct. 12 | St. Louis Rams at Washington Redskins | 1 p.m. |
| Sunday, Oct. 12 | Jacksonville Jaguars at Denver Broncos | 4:05 p.m. |
| Sunday, Oct. 12 | Green Bay Packers at Seattle Seahawks | 4:15 p.m. |
| Sunday, Oct. 12 | Dallas Cowboys at Arizona Cardinals | 4:15 p.m. |
| Sunday, Oct. 12 | Philadelphia Eagles at San Francisco 49ers | 4:15 p.m |
| Sunday, Oct. 12 | New England Patriots at San Diego Chargers | 8:15 p.m. |
| Monday, Oct. 13 | New York Giants at Cleveland Browns | 8:30 p.m. |
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